The Black Death
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The Black Death (also The Plague, and latter the Black Plague) was a devastating epidemic in Europe in the 14th century which is estimated to have killed about a third of the population. Most scientists believe that the Black Death was an outbreak of bubonic plague, a dreaded disease that has spread in pandemic form several times through history. The plague is caused by the bacterium Yersinia pestis which is spread by fleas with the help of animals like the black rat Rattus rattus) -what we would call today the sewer rat. Sometimes, the term "Black Death" is used for all outbreaks of plague and epidemics. 
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The Great Depression is the period of history that followed "Black Thursday", the stock market crash of Thursday, October 24, 1929. The events in the United States triggered a world-wide depression, which led to deflation and a great increase in unemployment. On the global scale, the market crash in the USA was a final straw in an already shaky world economic situation. Germany was suffering from hyperinflation of currency, and many of the Allied victors of World War I were having serious problems paying off huge war debts. In the late 1920s the American economy at first seemed immune to the mounting troubles, but with the start of the 1930s it crashed with startling rapidity.
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